Skip to main content

Stay in Santa Cruz Region's best hotels!

Filter by:


Star rating

5 stars 4 stars 3 stars 2 stars 1 star

Review score

Superb: 9+ Very good: 8+ Good: 7+ Pleasant: 6+
Our top picks Lowest price first Star rating and price Top reviewed

See the latest prices and deals by choosing your dates.

Chairu Eco Hotel 4 stars

Hotel in Santa Cruz de la Sierra

Chairu Eco Hotel features a shared lounge, terrace, a restaurant and bar in Santa Cruz de la Sierra. This 4-star hotel offers a concierge service and a tour desk. The staff are very efficient and friendly. The shower was wonderful with plenty of hot water and the whole room was very clean. The coffee shop downstairs was and added bonus. This is by far the nicest accommodation we have found in santa cruz.

Show more Show less
9
Superb
831 reviews
Price from
£40
per night

TRYP by Wyndham Santa Cruz 4 stars

Hotel in Santa Cruz de la Sierra

Situated in Santa Cruz de la Sierra, 1.6 km from Gabriel Rene Moreno Autonomous University, TRYP by Wyndham Santa Cruz features accommodation with an outdoor swimming pool, free private parking, a... Immaculately designed and maintained. Great reception staff.

Show more Show less
9
Superb
429 reviews
Price from
£53
per night

YVY CASA HOTEL

Hotel in Samaipata

Located in Samaipata, 10 km from Samaipata Fort, YVY CASA HOTEL provides accommodation with a garden, free private parking and a terrace. you feel part of the community

Show more Show less
9.2
Superb
262 reviews
Price from
£34
per night

Marriott Santa Cruz de la Sierra Hotel 5 stars

Hotel in Santa Cruz de la Sierra

Marriott Santa Cruz de la Sierra Hotel has an outdoor swimming pool, fitness centre, a shared lounge and terrace in Santa Cruz de la Sierra. the staff was exceptionally well trained, kindly and helpful

Show more Show less
9.1
Superb
311 reviews
Price from
£87
per night

Cosmopolitano Hotel Boutique 5 stars

Hotel in Santa Cruz de la Sierra

Offering an outdoor pool, Cosmopolitano Hotel Boutique is located in the historical centre of Santa Cruz de la Sierra. Guests can enjoy the on-site bar. Absolutely everything! Best hotel and service

Show more Show less
9.1
Superb
882 reviews
Price from
£67
per night

La Vida es Bella

Hotel in Samaipata

Set in Samaipata, 9 km from Samaipata Fort, La Vida es Bella offers accommodation with a garden, free private parking, a shared lounge and a terrace. Great location. Wonderful service. The best breakfast ever. A perfect place to rest and enjoy Samaipata.

Show more Show less
9.3
Superb
114 reviews
Price from
£47
per night

El Pueblito Hotel Boutique 4 stars

Hotel in Samaipata

Situated in Samaipata, 11 km from Samaipata Fort, El Pueblito Hotel Boutique features accommodation with an outdoor swimming pool, free private parking, a garden and a shared lounge. El Pueblito is a representation of a small town, each room representing parts if the town with exquisite decoration. You have a carpentry, bank, florist, artist’ house, chapel, etc… the view is magnificent. El Pueblito is a nice quiet place to relax. The food is very good as well. The family that owns and runs the hotel is very attentive and warm. 100% recommended!

Show more Show less
9.5
Exceptional
223 reviews
Price from
£69
per night

Alfonsina Hotel Boutique 5 stars

Hotel in Santa Cruz de la Sierra

Conveniently located only a 10-minute walk from Ventura Shopping Centre, Alfonsina Hotel Boutique. offers accommodations in Santa Cruz de la Sierra. Very beautiful hotel in Santa Cruz. The room we had was spacious, very comfortable and clean - and nicely decorated with lots of cinema references.The breakfast was delicious too. The hotel is a bit off from the historic center but it is a short ride or a slightly longer walk. We would definitely come back and stay here again!

Show more Show less
9.4
Superb
388 reviews
Price from
£74
per night

Hostal Juanita 1 stars

Hotel in Vallegrande

Hostal Juanita is located in Vallegrande. This 1-star hotel offers a shared lounge and room service. There is a terrace and guests can make use of free WiFi and free private parking. Centrally located. Beautifully decorated. Comfortable bed. Hot shower. Good Wi-Fi. Flexible checkout. Delicious breakfast. And very friendly and helpful staff (two sisters).

Show more Show less
9
Superb
10 reviews
Price from
£23
per night

Rústico & Hotel Boutique Las Churapas

Hotel in San José de Chiquitos

Rústico & Hotel Boutique Las Churapas features an outdoor swimming pool, garden, a terrace and bar in San José de Chiquitos. The hotel offers both free WiFi and free private parking. This is the best hotel in Bolivia! An incredible nature retreat, swim in crystalline water with macaws flying overhead and the smell of blooming gardenia in the air. Run by the kindest people. Highly recommend!

Show more Show less
9.2
Superb
87 reviews
Price from
£34
per night

Hotels with extra health and safety measures

Find hotels in Santa Cruz Region with added hygiene measures plus high cleanliness ratings

Safety features
Physical distancing
Cleanliness & disinfecting
Food & drink safety

Most booked hotels in Santa Cruz Region in the past month

See all

Santa Cruz Region's best hotels with breakfast

See all

Budget hotels in Santa Cruz Region

See all

Hotels in Santa Cruz Region that you can book without a credit card

See all

FAQs about hotels in Santa Cruz Region